Hyperbaric Oxygen Therapy For Alzheimer Prevention

Hyperbaric oxygen therapy (HBOT), an established medical treatment that involves breathing pure oxygen under pressure, improves cerebral blood flow and cognitive function in a mouse model of Alzheimer's disease in older patients with significant memory loss.

Results Of Hyperbaric Oxygen Therapy Experimentation On Mice:

  1. Researchers found that the treatment improved blood flow and reduced hypoxia (loss of oxygen) in the tissues of the brains of mice compared to a control group of mice that had not undergone the treatment. 

  2. By improving blood flow to the brain, reducing plaque levels, and reducing hypoxia, mice undergoing daily oxygen therapy showed improvements in their cognitive abilities, such as spatial recognition memory, contextual memory, and ability to remember emotional, social, spatial, and temporal events. 

  3. In a separate study with 15 genetically modified mice - mimicking the degeneration caused by Alzheimer's disease - the researchers reported that oxygen therapy prevented the formation of amyloid plaques in the brain and the removal of existing amyloids and plaque deposits. 

  4. The study also showed that increased blood flow to the brains of mice receiving oxygen therapy helped remove plaque from the brain and reduce inflammation, which is a hallmark of the disease. 

Taking The Mouse Model Results To Cure Humans:

The results of the mouse model, combined with similar effects observed in patients, suggest that HBOT may cause structural changes in blood vessels that are used. the first time hyperbaric oxygen therapy (HBOT)- a non-pharmaceutical method - has been shown to be effective in reversing the main activators of the early symptoms of Alzheimer's disease. 

In studies on mice and humans, researchers report that hyperbaric oxygen therapy (HBOT), in which pure oxygen is inhaled into a pressure chamber, can improve blood flow to the brain, eliminate Alzheimer's symptoms known as amyloid plaque and improve cognitive abilities. 

Researchers found that 60 sessions of oxygen therapy over 90 days increased blood flow in some areas of the brain and improved cognitive decline, memory, attention and information processing speed in six people aged 65. The study on hyperbaric oxygen treatment for vascular dementia shows that such therapy can improve cognitive function and improve the activities of daily life.

HBOT could help post-TBI patients by stimulating the growth of new blood vessels in the brain, enhancing cerebral blood flow volume and improving brain structure in supporting clinical trials. 

The Benefits Brought By HBOT:

Based on combined data from animal models of the disease the effects on human brain tissue were assessed using high-resolution magnetic resonance imaging (MRI) and computerized cognitive tests and the correlated results showed positive effects of HBOT in patients with mild cognitive impairment at all stages of dementia. 


The specific HBOT protocol significantly improved the cerebral blood flow in older patients, thereby reducing vascular dysfunction, reducing the volume of existing amyloid plaques and slowing the formation of new plaques. 


Amyloid plaques are hardened clumps of beta-amyloid proteins that, due to their low oxygen content, reduce the blood flow to the brain and cause hypoxia in patients who suffer before the onset of dementia. A number of hyperbaric treatments in older patients suffering from memory loss have shown an improvement in blood flow in the brain, with real improvements in cognitive performance. The study results showed increased blood flow and increased oxygen supply to the brain of patients with cognitive impairments. 


Conclusion:

The first PET scan to document an improvement in brain metabolism in an Alzheimer's patient treated with hyperbaric oxygen therapy (HBOT) was performed. It showed that the treatment improved cognitive function in patients with conditions such as vascular dementia and mild cognitive impairment, as well as in patients with Alzheimer's disease. It was pointed out that the PET scan was not considered by experts a sufficient reason to recommend the therapy and that a larger set of studies with appropriate controls is needed. 


The first PET scan documents a case of improvement in brain metabolism in Alzheimer's disease in a patient treated with hyperbaric oxygen therapy (HBOT). For the first time, HBOT has emerged as a promising treatment to reverse the main drivers of the early symptoms of the disease, dementia that treats brain and cognitive problems. Many dementia patients have been treated, including an astonishing improvement in PET metabolism, and that widespread similar results could be large enough for a clinical trial.

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